Subtotal:
$445.00
$555.00
| Cat.#: 11289 | ||||
| Product Name: Human CTLA-4 Protein | ||||
| Size : 10 µg, 50 µg and 100 µg | ||||
| Synonyms: CTLA4;CD152 | ||||
| Target: CTLA-4 | ||||
| UNIPROT ID: P16410 | ||||
| Description: Recombinant human CTLA-4 protein with C-terminal human Fc tag | ||||
| Background: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. | ||||
| Species/Host: HEK293 | ||||
| Molecular Weight: The protein has a predicted molecular mass of 39.6 kDa after removal of the signal peptide.The apparent molecular mass of CTLA4-hFc is approximately 40-55 kDa due to glycosylation. | ||||
| Molecular Characterization: CTLA-4(Gln36-Ser161) hFc(Glu99-Ala330) | ||||
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. | ||||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||||
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