Subtotal:
$347.00
$479.00
| Cat.#: 11853 | ||
| Product Name: Human LRP6 Protein | ||
| Size : 10 µg, 50 µg and 100 µg | ||
| Synonyms: ADCAD2;STHAG7 | ||
| Target: LRP6 | ||
| UNIPROT ID: O75581 | ||
| Description: Recombinant Human LRP6 Protein with C-terminal 6xHis tag | ||
| Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009] | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The protein has a predicted molecular mass of 153.1 kDa after removal of the signal peptide. The apparent molecular mass of LRP6-His is approximately 130-250 kDa due to glycosylation. | ||
| Molecular Characterization: LRP6(Ala20-Ala1370) 6×His tag | ||
| Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
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