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Human MUC18 Protein, His Tag

Recombinant human MUC18 protein with C-terminal 6XHis tag


Cat.#:  11524

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11524
Product Name:   Human MUC18 Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   Cell surface glycoprotein MUC18;ell surface glycoprotein P1H12;elanoma cell adhesion molecule;elanoma-associated antigen A32;elanoma-associated antigen MUC18;-endo 1 endothelial-associated antigen;D146
Target:    MUC18
UNIPROT ID:    P43121
Description:    Recombinant human MUC18 protein with C-terminal 6xHis tag
Background:     Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.[UniProtKB/Swiss-Prot Function]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 60.6 kDa after removal of the signal peptide. The apparent molecular mass of MUC18-His is approximately 70-100 kDa due to glycosylation.
Molecular Characterization:    MUC18(Val24-Gly559) 6×His tag
Purity:    The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human MUC18  Protein, His Tag on SDS-PAGE under reducing condition.