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Human UPA Protein, His Tag

Recombinant human UPA protein with C-terminal 6XHis tag
5/5

$415.00

Cat.#:  11395

   Size:   100 μg

In Stock

          Product Description          
Cat.#:     11395
Product Name:   Human UPA Protein
Size :    10 µg, 50 µg and 100 µg
Synonyms:   ATF;BDPLT5;QPD;u-PA;UPA;URK
Target:    UPA
UNIPROT ID:    P00749
Description:    Recombinant human UPA protein with C-terminal 6xHis tag
Background:     This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Species/Host:    HEK293
Molecular Weight:    The protein has a predicted molecular mass of 47.2 kDa after removal of the signal peptide. The apparent molecular mass of UPA-His is approximately 55-70 kDa due to glycosylation.
Molecular Characterization:    UPA(Ser21-Leu431) 6×His tag
Purity:    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution:    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human UPA Protein, His Tag on SDS-PAGE under reducing condition.
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