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IGF1R (DMC684) IgG1 Chimeric mAb

Anti-IGF1R (DMC684) IgG1 Chimeric Monoclonal Antibody


Cat.#:  28282

   Size:   100 μg

In Stock

          Product Description          
Cat.#:   28282
Product Name:   Anti-IGF1R(DMC684) IgG1 Chimeric Monoclonal Antibody
Synonyms:   CD221; IGFIR; IGFR; JTK13
Description:    Anti-IGF1R antibody(DMC684) IgG1 Chimeric Monoclonal Antibody
Background:    This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq; May 2014]
Applications:    Flow Cyt
Recommended Dilutions:    Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit:Human Fc chimeric IgG1
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human IGF1R
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. IGF1R protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-IGF1R (DMC684) on Expi293 cells transfected with human IGF1R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).